ๆŠ—ๅŽŸๆๅ‘ˆ็ป†่ƒž

antigen processing

The mechanisms by which peptide ligands for MHC molecules are generated

antigen presentation

the mechanisms that convey peptide/MHC complexes to the surface of APCs

APC ไธป่ฆๅˆ†ไธบไธ‰็ฑป:ไธ“่Œๆ€ง APC(professional antigen-presenting cells, pAPCs)ใ€้žไธ“่Œๆ€ง APC ๅ’Œ่กจ่พพ MHC I ็ฑปๅˆ†ๅญ็š„้ถ็ป†่ƒž

ไธ“่ŒAPC

  • DC
  • ๅ•ๆ ธ/ๅทจๅ™ฌ็ป†่ƒž
  • ๆท‹ๅทด็ป†่ƒž

้žไธ“่ŒAPC

้žไธ“่Œๆ€ง APC(non-professional APC)ๅช่ƒฝๅœจไธ€ๅฎšๆกไปถไธ‹(ไพ‹ๅฆ‚็‚Ž็—‡ๅ› ็ด ็š„ๅˆบๆฟ€ๆˆ–็ป†่ƒžๅ› ๅญ็š„ไฝœ็”จ)ๆ‰่ƒฝ่ขซ่ฏฑๅฏผ่กจ่พพ MHC II็ฑปๅˆ†ๅญๅ’Œๅ…ฑๅˆบๆฟ€ๅˆ†ๅญ;ๅฎƒไปฌๆ‘„ๅ–ใ€ๅŠ ๅทฅๆŠ—ๅŽŸๅ’Œๆๅ‘ˆๆŠ—ๅŽŸไฟกๆฏ็š„่ƒฝๅŠ›่พƒไธ“่Œๆ€ง APCๅผฑใ€‚้žไธ“่Œๆ€ง APCไธป่ฆๅŒ…ๆ‹ฌๅ†…็šฎ็ป†่ƒžใ€ๆˆ็บค็ปด็ป†่ƒžใ€ไธŠ็šฎ้—ด็šฎ็ป†่ƒžๅ’Œๅ—œ้…ธๆ€ง็ฒ’็ป†่ƒž็ญ‰ใ€‚้žไธ“่Œๆ€ง APC ๅŠ ๅทฅๅ’Œๆๅ‘ˆๆŠ—ๅŽŸๅฏ่ƒฝๅ‚ไธŽ็‚Ž็—‡ๅๅบ”ๅ’ŒๆŸไบ›่‡ช่บซๅ…็–ซ็—…็š„ๅ‘็”Ÿใ€‚

่กจ่พพ MHC I ็ฑปๅˆ†ๅญ็š„้ถ็ป†่ƒž

ไธ€็ฑป็‰นๆฎŠ็š„้žไธ“่ŒAPC

้ถ็ป†่ƒž้€šๅธธๆŒ‡่ขซ็—…ๆฏ’ๆˆ–่ƒžๅ†…่Œๆ„ŸๆŸ“็š„็ป†่ƒžไปฅๅŠ็ชๅ˜็š„่‡ช่บซ็ป†่ƒžใ€‚่ฟ™ไบ›็ป†่ƒž็ป„ๆˆๆ€ง่กจ่พพMIC I ็ฑปๅˆ†ๅญ,่ƒฝๅŠ ๅทฅๅ†…ๆบๆ€งๆŠ—ๅŽŸ(็—…ๆฏ’็›ธๅ…ณๆŠ—ๅŽŸใ€็ป†่Œ็›ธๅ…ณๆŠ—ๅŽŸๆˆ–็ชๅ˜็š„่‡ช่บซๆŠ—ๅŽŸ็ญ‰)ๅนถไปฅๆŠ—ๅŽŸ่‚ฝ/MIC I็ฑปๅˆ†ๅญๅคๅˆ็‰ฉ็š„ๅฝขๅผๅฐ†ๆŠ—ๅŽŸไฟกๆฏๆๅ‘ˆ็ป™CD8*CTL,CTL. ่ƒฝๅคŸ่ฏ†ๅˆซๅนถ็‰นๅผ‚ๆ€งๅœฐๆ€ไผค่ฟ™ไบ›้ถ็ป†่ƒžใ€‚

Dendritic cell

APC ๅ››็ง้€”ๅพ„

  1. MHC-I
  2. MHC-II
  3. ไบคๅ‰ๆๅ‘ˆ
  4. ่„‚็ฑปๅˆ†ๅญ็š„CD1ๆๅ‘ˆ
Interactive Graph
Table Of Contents
ๆŠ—ๅŽŸๆๅ‘ˆ็ป†่ƒž
ไธ“่ŒAPC
้žไธ“่ŒAPC
่กจ่พพ MHC I ็ฑปๅˆ†ๅญ็š„้ถ็ป†่ƒž
Dendritic cell
APC ๅ››็ง้€”ๅพ„